On Friday (or maybe a little later), CAPT Stephen Bowen will become the first Submariner in space when he blasts off onboard the Space Shuttle Endeavour as part of STS-126. I know he'll do us proud!
Update 0803 15 Nov: Endeavour took off with CAPT Bowen aboard as scheduled. As commenter Rubber Ducky points out, it turns out that CAPT Bowen is not the first Submariner in space; that honor goes to former astronaut Michael J. McCulley, who served on 3 submarines while enlisted before getting picked up for a commissioning program and going Navy Air. McCulley was the pilot for STS-34 in 1989.